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- Ba8d29f5c21aa9c50a36e420bad80e7f8 NCIT_P378 "NCI" @default.
- Ba8d29f5c21aa9c50a36e420bad80e7f8 type Axiom @default.
- Ba8d29f5c21aa9c50a36e420bad80e7f8 annotatedProperty IAO_0000115 @default.
- Ba8d29f5c21aa9c50a36e420bad80e7f8 annotatedSource NCIT_C17967 @default.
- Ba8d29f5c21aa9c50a36e420bad80e7f8 annotatedTarget "Mammalian P-glycoproteins are encoded by the MDR gene family and belong to the ATP-binding cassette vectorial transport protein class; the CFTR chloride channel is also a family member. The human multidrug resistance 1 (MDR1) gene responds to environmental stress, including various anticancer agents. It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents. MDR1 and MDR2 P-glycoproteins are large apical cell membrane proteins overproduced in multidrug-resistant (MDR) cancer cells resistant to diverse hydrophobic drugs. P-glycoproteins act as pumps able to extrude drugs from cells at the cost of ATP hydrolysis. MDR is primarily due to increased drug extrusion from the resistant cell. Defense against xenobiotics may be a natural function of these P-glycoproteins." @default.