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- Ba8d83d9751dc08838bb94ddffc7f51b2 NCIT_P378 "NCI" @default.
- Ba8d83d9751dc08838bb94ddffc7f51b2 type Axiom @default.
- Ba8d83d9751dc08838bb94ddffc7f51b2 annotatedProperty IAO_0000115 @default.
- Ba8d83d9751dc08838bb94ddffc7f51b2 annotatedSource NCIT_C61759 @default.
- Ba8d83d9751dc08838bb94ddffc7f51b2 annotatedTarget "A benzazepine derivative with vasodilatory and antihypertensive properties. Fenoldopam, a dopamine (DA) receptor agonist, binds specifically to peripheral DA1 receptors and to alpha-2 adrenoceptors with moderate affinity. However, this agent exhibits no significant affinity to DA2, other alpha adrenergic, beta adrenergic, muscarinic, or serotonergic receptors. Receptor binding modulates the transmembrane flux of ions, thereby stimulating adenylate cyclase activity, as well as the release of prolactin. This results in vasodilatation, increased renal blood flow thereby enhancing natriuresis and diuresis leading to a lowering in diastolic blood pressure." @default.