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- Ba92e7aa5d75efb634f81c1e5c600bb94 NCIT_P378 "NCI" @default.
- Ba92e7aa5d75efb634f81c1e5c600bb94 type Axiom @default.
- Ba92e7aa5d75efb634f81c1e5c600bb94 annotatedProperty IAO_0000115 @default.
- Ba92e7aa5d75efb634f81c1e5c600bb94 annotatedSource NCIT_C61848 @default.
- Ba92e7aa5d75efb634f81c1e5c600bb94 annotatedTarget "A cardiovascular bipyridine agent and phosphodiesterase (PDE) III inhibitor, with positive inotropic and vasodilator activities. Upon administration, milrinone selectively inhibits PDE-mediated degradation of cyclic adenosine monophosphate (cAMP) in the heart and vascular muscles, thereby increasing cAMP and activates protein kinase A (PKA). This leads to phosphorylation of calcium ion channels and improve myocardium contractile force. Milrinone also causes vasodilation in arteriolar and venous vascular smooth muscle." @default.