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- Ba9f6d7e929ee6cfed6d977b5abcaf15b NCIT_P378 "NCI" @default.
- Ba9f6d7e929ee6cfed6d977b5abcaf15b type Axiom @default.
- Ba9f6d7e929ee6cfed6d977b5abcaf15b annotatedProperty IAO_0000115 @default.
- Ba9f6d7e929ee6cfed6d977b5abcaf15b annotatedSource NCIT_C47753 @default.
- Ba9f6d7e929ee6cfed6d977b5abcaf15b annotatedTarget "The hydrochloride salt form of thiothixene, a thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor trigger zone, thereby decreasing dopamine activity leading to decreased stimulation of the vomiting center and psychotic effects, such as hallucinations and delusions. In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic receptors." @default.