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- Baa2088a9f50beea8c4fe61e9dec9d075 NCIT_P378 "NCI" @default.
- Baa2088a9f50beea8c4fe61e9dec9d075 type Axiom @default.
- Baa2088a9f50beea8c4fe61e9dec9d075 annotatedProperty IAO_0000115 @default.
- Baa2088a9f50beea8c4fe61e9dec9d075 annotatedSource NCIT_C132684 @default.
- Baa2088a9f50beea8c4fe61e9dec9d075 annotatedTarget "A vaccine composed of a peptide derived from histone H3.3 containing the amino acid substitution mutation lysine (Lys) 27-to-methionine (H3.3K27M), with potential immunoactivating and antineoplastic activities. Upon administration of the H3.3K27M-specific peptide vaccine, the immune system may exert a cytotoxic T-lymphocyte (CTL)-mediated immune response against H3.3K27M-expressing tumor cells. The H3.3K27M mutation alters the methylation and acetylation profile of the histone H3 variant H3.3 at Lys 27. Modification of H3.3 at Lys 27 regulates gene expression, and the H3.3K27M mutation occurs in a variety of cancer cell types." @default.