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- Baa5c9665b5281545360bf8a24d905abb NCIT_P378 "NCI" @default.
- Baa5c9665b5281545360bf8a24d905abb type Axiom @default.
- Baa5c9665b5281545360bf8a24d905abb annotatedProperty IAO_0000115 @default.
- Baa5c9665b5281545360bf8a24d905abb annotatedSource NCIT_C71621 @default.
- Baa5c9665b5281545360bf8a24d905abb annotatedTarget "A pipecolinate derivative. Functioning as a modulator of P-glycoprotein (P-gp) and multidrug resistance protein (MRP-1), biricodar restores drug sensitivity to cells expressing P-glycoprotein and MRP1, the cellular efflux pumps that are the major causes in tumor cell resistance to chemotherapeutic agents. This agent binds directly to Pgp and MRP-1 and inhibits efflux pump activity, resulting in increased intracellular accumulation and retention of cytotoxic agents." @default.