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- Baa71129282cc40abfc601c573672f0fe NCIT_P378 "NCI" @default.
- Baa71129282cc40abfc601c573672f0fe type Axiom @default.
- Baa71129282cc40abfc601c573672f0fe annotatedProperty IAO_0000115 @default.
- Baa71129282cc40abfc601c573672f0fe annotatedSource NCIT_C80333 @default.
- Baa71129282cc40abfc601c573672f0fe annotatedTarget "The fumarate salt of an orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis." @default.