Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Baa917750c91719cba4de367e56fc0ee8> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Baa917750c91719cba4de367e56fc0ee8 NCIT_P378 "BIOCARTA" @default.
- Baa917750c91719cba4de367e56fc0ee8 type Axiom @default.
- Baa917750c91719cba4de367e56fc0ee8 annotatedProperty NCIT_P325 @default.
- Baa917750c91719cba4de367e56fc0ee8 annotatedSource NCIT_C39119 @default.
- Baa917750c91719cba4de367e56fc0ee8 annotatedTarget "IL-18 is a pro-inflammatory cytokine similar in structure and mechanism of action to IL-1 beta. Formation of active IL-18 by macrophages requires cleavage of an inactive precursor by caspase-1 protease, also termed the IL-1 converting enzyme (ICE). One of the key biological responses induced by IL-18 is that, in combination with IL-12, it stimulates Th1 cell differentiation and involvement in immune responses. IL-18 was originally known as interferon-gamma-inducing factor, named after its induction of interferon-gamma production. Up-regulation of Fas ligand in Th1 cells by IL-18 may increase apoptosis of Fas receptor expressing cells that interact with the activated Th1 cells. This induction of apoptosis may allow IL-18 to have anti-tumor activity and may also play a role in chronic inflammatory and autoimmune conditions. (This definition may be outdated - see the DesignNote.)" @default.