Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bab1cd0a85c8931cf49a08e22e61768e0> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bab1cd0a85c8931cf49a08e22e61768e0 NCIT_P378 "NCI" @default.
- Bab1cd0a85c8931cf49a08e22e61768e0 type Axiom @default.
- Bab1cd0a85c8931cf49a08e22e61768e0 annotatedProperty IAO_0000115 @default.
- Bab1cd0a85c8931cf49a08e22e61768e0 annotatedSource NCIT_C148488 @default.
- Bab1cd0a85c8931cf49a08e22e61768e0 annotatedTarget "A Bcl-2 homology (BH)-3 mimetic and selective inhibitor of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL, with potential pro-apoptotic and antineoplastic activities. Upon administration, pelcitoclax specifically binds to and inhibits the activity of the pro-survival proteins Bcl-2 and Bcl-XL. This restores apoptotic processes and inhibits cell proliferation in Bcl-2/Bcl-XL-dependent tumor cells. Bcl-2 and Bcl-XL, proteins belonging to the Bcl-2 family that are overexpressed in many cancers, play an important role in the negative regulation of apoptosis; tumor expression is associated with increased drug resistance and cancer cell survival." @default.