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- Babe069961768e7be73f13bc7b27a4cfd NCIT_P378 "NCI" @default.
- Babe069961768e7be73f13bc7b27a4cfd type Axiom @default.
- Babe069961768e7be73f13bc7b27a4cfd annotatedProperty IAO_0000115 @default.
- Babe069961768e7be73f13bc7b27a4cfd annotatedSource NCIT_C53434 @default.
- Babe069961768e7be73f13bc7b27a4cfd annotatedTarget "A phytonutrient and plant indole found in cruciferous vegetables including broccoli, Brussels sprouts, cabbage, cauliflower and kale, with potential anti-androgenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown." @default.