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- Bacabf17db7df6cc7321c5376e2bc3541 NCIT_P378 "NCI" @default.
- Bacabf17db7df6cc7321c5376e2bc3541 type Axiom @default.
- Bacabf17db7df6cc7321c5376e2bc3541 annotatedProperty IAO_0000115 @default.
- Bacabf17db7df6cc7321c5376e2bc3541 annotatedSource NCIT_C192804 @default.
- Bacabf17db7df6cc7321c5376e2bc3541 annotatedTarget "An orally bioavailable selective inhibitor of cyclin-dependent kinase (CDK) types 4 (CDK4) and 6 (CDK6), with potential antineoplastic activity. Upon oral administration, CDK4/6 inhibitor SPH4336 selectively targets and inhibits the activity of CDK4 and CDK6, which inhibits the phosphorylation of retinoblastoma protein (Rb) early in the G1 phase, prevents CDK-mediated G1-S-phase transition and leads to cell cycle arrest. This suppresses DNA replication and decreases tumor cell proliferation. CDK4 and 6 are serine/threonine kinases that are upregulated in many tumor cell types and play a key role in the regulation of both cell cycle progression from the G1-phase into the S-phase and tumor cell proliferation." @default.