Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bacba68fa2fb47f80b21108ef85c2a2f5> ?p ?o ?g. }
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- Bacba68fa2fb47f80b21108ef85c2a2f5 hasDbXref "GOC:bf" @default.
- Bacba68fa2fb47f80b21108ef85c2a2f5 hasDbXref "PMID:12773372" @default.
- Bacba68fa2fb47f80b21108ef85c2a2f5 hasDbXref "PMID:34659217" @default.
- Bacba68fa2fb47f80b21108ef85c2a2f5 type Axiom @default.
- Bacba68fa2fb47f80b21108ef85c2a2f5 annotatedProperty IAO_0000115 @default.
- Bacba68fa2fb47f80b21108ef85c2a2f5 annotatedSource GO_0007249 @default.
- Bacba68fa2fb47f80b21108ef85c2a2f5 annotatedTarget "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs)." @default.