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- Baceee16232c69a466f7636f36cee40ab NCIT_P378 "NCI" @default.
- Baceee16232c69a466f7636f36cee40ab type Axiom @default.
- Baceee16232c69a466f7636f36cee40ab annotatedProperty IAO_0000115 @default.
- Baceee16232c69a466f7636f36cee40ab annotatedSource NCIT_C1022 @default.
- Baceee16232c69a466f7636f36cee40ab annotatedTarget "An orally available antimetabolite composed of the 1-ethoxymethyl derivative of 5-fluorouracil (5-FU) and the dihydropyrimidine dehydrogenase (DPYD) inhibitor 3-cyano-2,6-dihydroxypyridine (CNDP) in a 1:1 molar ratio, with antineoplastic activity. Upon administration, the prodrug emitefur is converted into 5-FU, while CNDP prevents the degradation of 5-FU by inhibiting DPYD and thereby prolonging the half-life of 5-FU. This increases 5-FU's concentration and thus its antitumor activity through inhibition of DNA and RNA synthesis, as well as inhibition of thymidylate synthase activity. In addition, by inhibiting the formation of 5-FU metabolites, some toxic effects associated with these metabolites may be reduced. DPYD is the rate-limiting enzyme in the catabolism of 5-FU." @default.