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- Badf97311fd0904993eeae896d6430758 NCIT_P378 "NCI" @default.
- Badf97311fd0904993eeae896d6430758 type Axiom @default.
- Badf97311fd0904993eeae896d6430758 annotatedProperty IAO_0000115 @default.
- Badf97311fd0904993eeae896d6430758 annotatedSource NCIT_C84871 @default.
- Badf97311fd0904993eeae896d6430758 annotatedTarget "An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential antineoplastic activity. IGF-1R/IR inhibitor KW-2450 selectively binds to and inhibits the activities of IGF-1R and IR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-R1 and IR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in the stimulation of cellular proliferation, oncogenic transformation, and suppression of apoptosis." @default.