Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Baf2da028026285cbeb95e7272a7dc50a> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Baf2da028026285cbeb95e7272a7dc50a NCIT_P378 "NCI" @default.
- Baf2da028026285cbeb95e7272a7dc50a type Axiom @default.
- Baf2da028026285cbeb95e7272a7dc50a annotatedProperty IAO_0000115 @default.
- Baf2da028026285cbeb95e7272a7dc50a annotatedSource NCIT_C163023 @default.
- Baf2da028026285cbeb95e7272a7dc50a annotatedTarget "A cancer vaccine containing epidermal growth factor (EGF), with immunomodulating and antineoplastic activities. Upon administration of the EGF vaccine EGF-PTI, EGF induces an immune response against EGFR, which results in the formation of anti-EGF-specific neutralizing antibodies. This causes binding of the anti-EGF antibodies to endogenous EGF, reduces levels of circulating EGF and prevents the binding of EGF to its receptor EGFR. This prevents EGF/EGFR pathway activation and may result in an inhibition of proliferation in EGFR-overexpressing tumor cells. EGF/EGFR-mediated signaling is overactivated in certain cancer types and drives tumor cell proliferation and progression." @default.