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- Baf4d0437fded0991581da35638d6bfbc NCIT_P378 "NCI" @default.
- Baf4d0437fded0991581da35638d6bfbc type Axiom @default.
- Baf4d0437fded0991581da35638d6bfbc annotatedProperty IAO_0000115 @default.
- Baf4d0437fded0991581da35638d6bfbc annotatedSource NCIT_C29134 @default.
- Baf4d0437fded0991581da35638d6bfbc annotatedTarget "The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)" @default.