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- Bafe2032afc7eb65c31191ecfd9348f8b NCIT_P378 "NCI" @default.
- Bafe2032afc7eb65c31191ecfd9348f8b type Axiom @default.
- Bafe2032afc7eb65c31191ecfd9348f8b annotatedProperty IAO_0000115 @default.
- Bafe2032afc7eb65c31191ecfd9348f8b annotatedSource NCIT_C47970 @default.
- Bafe2032afc7eb65c31191ecfd9348f8b annotatedTarget "The dihydrate form of cephradine, a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephradine dihydrate binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis." @default.