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- Bb033f209e087e619c605a64cdc2f15da NCIT_P378 "NCI" @default.
- Bb033f209e087e619c605a64cdc2f15da type Axiom @default.
- Bb033f209e087e619c605a64cdc2f15da annotatedProperty IAO_0000115 @default.
- Bb033f209e087e619c605a64cdc2f15da annotatedSource NCIT_C106120 @default.
- Bb033f209e087e619c605a64cdc2f15da annotatedTarget "An orally available spiro-oxindole HDM2 (human double minute 2) antagonist with potential antineoplastic activity. Upon oral administration, the p53-HDM2 protein-protein interaction inhibitor MI-773 binds to HDM2, preventing the binding of the HDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction, the proteasome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and lead to the p53-mediated induction of tumor cell apoptosis. HDM2, a zinc finger protein and a negative regulator of the p53 pathway, is often overexpressed in cancer cells. It has been implicated in cancer cell proliferation and survival." @default.