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- Bb13a3fb658c9eec74dde4a52124e1fde NCIT_P378 "BIOCARTA" @default.
- Bb13a3fb658c9eec74dde4a52124e1fde type Axiom @default.
- Bb13a3fb658c9eec74dde4a52124e1fde annotatedProperty NCIT_P325 @default.
- Bb13a3fb658c9eec74dde4a52124e1fde annotatedSource NCIT_C38996 @default.
- Bb13a3fb658c9eec74dde4a52124e1fde annotatedTarget "The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells. (This definition may be outdated - see the DesignNote.)" @default.