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- Bb151076cda298fcce47ef00b49cf6abb NCIT_P378 "NCI" @default.
- Bb151076cda298fcce47ef00b49cf6abb type Axiom @default.
- Bb151076cda298fcce47ef00b49cf6abb annotatedProperty IAO_0000115 @default.
- Bb151076cda298fcce47ef00b49cf6abb annotatedSource NCIT_C81539 @default.
- Bb151076cda298fcce47ef00b49cf6abb annotatedTarget "A thyroid hormone receptor isoform beta-1 liver-selective analog with antilipidemic and antiatherosclerotic activity. In animal models sobetirome reduced serum lipids, decreased cholesterol levels, and stimulated steps of reverse cholesterol transport, which promotes the reverse transport of cholesterol from atherogenic macrophages back to the liver for excretion. In humans, sobetirome lowered plasma LDL cholesterol and reduced plasma triglycerides, while its liver-selective activity helped avoid the side effects seen with many other thyromimetic agents." @default.