Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bb158849be7f057f80936ce237b3ed8c0> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bb158849be7f057f80936ce237b3ed8c0 NCIT_P378 "NCI" @default.
- Bb158849be7f057f80936ce237b3ed8c0 type Axiom @default.
- Bb158849be7f057f80936ce237b3ed8c0 annotatedProperty IAO_0000115 @default.
- Bb158849be7f057f80936ce237b3ed8c0 annotatedSource NCIT_C49178 @default.
- Bb158849be7f057f80936ce237b3ed8c0 annotatedTarget "A nanoparticle-based formulation composed of a non-viral plasmid DNA vector encoding the human pro-inflammatory cytokine interleukin-12 (IL-12) encapsulated in a biodegradable, biocompatible lipoplex composed of polyethylene glycol (PEG), polyethylenimine (PEI), and cholesterol, with potential immunoactivating and antineoplastic activities. Upon intraperitoneal (IP) delivery of the PEG-PEI-cholesterol lipopolymer-encased IL-12 DNA plasmid vector IMNN-001, the lipoplex is endocytosed by nearby cells, and the plasmid DNA is transported into the nucleus, which leads to local expresssion of IL-12. In turn, the increased IL-12 production at the tumor site activates the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma (IFN-g) and promoting cytotoxic T-cell responses against tumor cells." @default.