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- Bb18c1d33e4befda238c4675e9facdb3f NCIT_P378 "BIOCARTA" @default.
- Bb18c1d33e4befda238c4675e9facdb3f type Axiom @default.
- Bb18c1d33e4befda238c4675e9facdb3f annotatedProperty NCIT_P325 @default.
- Bb18c1d33e4befda238c4675e9facdb3f annotatedSource NCIT_C39073 @default.
- Bb18c1d33e4befda238c4675e9facdb3f annotatedTarget "Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth factors. CFU-GEMM cells are a key intermediate in the differentiation of granulocytes, erythrocytes, monocytes and megakaryocytes. Erythropoietin (EPO) is a cytokine produced in the kidneys that, along with other cytokines, induces red blood cell (erythrocyte) differentiation in the bone marrow from CFU-GEMM cells. As the erythrocyte lineage progresses, cells lose their nuclei, and move out of the bone marrow into circulation. The ability of EPO to selectively induce red blood cell differentiation has allowed extensive therapeutic use of the recombinant form of this cytokine to treat anemias. (This definition may be outdated - see the DesignNote.)" @default.