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- Bb1c0e70f433196b34fca0658bbfc2e5f NCIT_P378 "NCI" @default.
- Bb1c0e70f433196b34fca0658bbfc2e5f type Axiom @default.
- Bb1c0e70f433196b34fca0658bbfc2e5f annotatedProperty IAO_0000115 @default.
- Bb1c0e70f433196b34fca0658bbfc2e5f annotatedSource NCIT_C113162 @default.
- Bb1c0e70f433196b34fca0658bbfc2e5f annotatedTarget "An inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Upon administration, mivavotinib may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies." @default.