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- Bb2361eea2e33b24fac4b9c0c96fd897f NCIT_P378 "NCI" @default.
- Bb2361eea2e33b24fac4b9c0c96fd897f type Axiom @default.
- Bb2361eea2e33b24fac4b9c0c96fd897f annotatedProperty IAO_0000115 @default.
- Bb2361eea2e33b24fac4b9c0c96fd897f annotatedSource NCIT_C64767 @default.
- Bb2361eea2e33b24fac4b9c0c96fd897f annotatedTarget "A second-generation E2F1 pathway activator with potential antineoplastic activity. ARQ 171 induces the expression of E2F transcription factor 1, thereby activating the E2F1-mediated checkpoint process. E2F1, down-regulated in cancer cells, regulates expression of genes involved in the cell cycle progression from G1 into S phase. The G1/S checkpoint process selectively induces cell cycle arrest in cancer cells with irreparable DNA damages and triggers subsequent apoptosis, while allowing cell division to proceed in cells without or with minor reparable DNA damage. As a result, this agent exerts anti-tumor activity through checkpoint activation independent of p53 mediated tumor suppression." @default.