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- Bb280b7af10d3d89d00608088f4629099 NCIT_P378 "NCI" @default.
- Bb280b7af10d3d89d00608088f4629099 type Axiom @default.
- Bb280b7af10d3d89d00608088f4629099 annotatedProperty IAO_0000115 @default.
- Bb280b7af10d3d89d00608088f4629099 annotatedSource NCIT_C2221 @default.
- Bb280b7af10d3d89d00608088f4629099 annotatedTarget "A recombinant and modified form of the endogenous cytokine human interferon (IFN) beta-1b, with antiproliferative, antiviral and immunomodulating activities. Upon administration, interferon beta-1b targets and binds to specific type I IFN receptors, which eventually results in the transcription and translation of genes containing an interferon-specific response element and leads to the production of various anti-viral proteins and modulates the production of various immune-modulating proteins. This reduces the production of certain pro-inflammatory cytokines while upregulating the anti-inflammatory cytokine interleukin 10 (IL-10), upregulates the expression of major histocompatibility (MHC) I proteins which allows for increased presentation of peptides derived from viral antigens, and activates CD8+ T cells as well as other immune cells. Endogenous IFN-beta-1b is produced following viral infection and it plays a key role in innate immune response against viral pathogens." @default.