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- Bb362c33e8c3105ee5351eb5474420817 NCIT_P378 "NCI" @default.
- Bb362c33e8c3105ee5351eb5474420817 type Axiom @default.
- Bb362c33e8c3105ee5351eb5474420817 annotatedProperty IAO_0000115 @default.
- Bb362c33e8c3105ee5351eb5474420817 annotatedSource NCIT_C61083 @default.
- Bb362c33e8c3105ee5351eb5474420817 annotatedTarget "Pentavalent antimony (Sb) in differential complex formation with gluconic acid with leishmanicidal and potential antineoplastic activities. The Sb moiety of sodium stibogluconate (SSG) may inhibit protein tyrosine phosphorylases (PTPases) by covalently modifying sulfhydryl groups in PTPase cysteine residues, resulting in specific inactivation of SH2 domain-containing tyrosine phosphatases-1 and -2 (SHP-1 and SHP-2), PTPases which negatively regulate interferon (IFN) signaling; enhancement of IFN-induced Stat1 tyrosine phosphorylation; and induction of cellular protein tyrosine phosphorylation. SSG in combination with IFN-alpha may synergize to overcome tumor cell resistance to IFN-alpha-mediated apoptosis." @default.