Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bb36a3e6e69a9bd85e6b844cd873adaaf> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bb36a3e6e69a9bd85e6b844cd873adaaf NCIT_P378 "NCI" @default.
- Bb36a3e6e69a9bd85e6b844cd873adaaf type Axiom @default.
- Bb36a3e6e69a9bd85e6b844cd873adaaf annotatedProperty IAO_0000115 @default.
- Bb36a3e6e69a9bd85e6b844cd873adaaf annotatedSource NCIT_C91731 @default.
- Bb36a3e6e69a9bd85e6b844cd873adaaf annotatedTarget "An orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Apitolisib inhibits both PI3K kinase and mTOR kinase, which may result in tumor cell apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated in a PI3K-independent fashion." @default.