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- Bb3896f9d2079dea2cd018a339898c89a NCIT_P378 "NCI" @default.
- Bb3896f9d2079dea2cd018a339898c89a type Axiom @default.
- Bb3896f9d2079dea2cd018a339898c89a annotatedProperty IAO_0000115 @default.
- Bb3896f9d2079dea2cd018a339898c89a annotatedSource NCIT_C29410 @default.
- Bb3896f9d2079dea2cd018a339898c89a annotatedTarget "An alpha-pyridylmethylsulfinyl benzimidazole and a selective and irreversible proton pump inhibitor with antisecretory property. Rabeprazole enters the parietal cell and accumulates in the acidic secretory canaliculi where the agent is activated by a proton-catalyzed process that results in the formation of a thiophilic sulfonamide or sulfenic acid. The activated rabeprazole forms covalent bonds with the sulfhydryl amino acids cysteine on the extracellular domain of the proton pump (H+/K+ ATPase) at the secretory surface, thereby inhibiting the transport of hydrogen ions, via exchange with potassium ions, into the gastric lumen. Binding to cysteine 813, in particular, is essential for inhibition of gastric acid production." @default.