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- Bb39f08cae445af10f54f4c71092fc00f NCIT_P378 "NCI" @default.
- Bb39f08cae445af10f54f4c71092fc00f type Axiom @default.
- Bb39f08cae445af10f54f4c71092fc00f annotatedProperty IAO_0000115 @default.
- Bb39f08cae445af10f54f4c71092fc00f annotatedSource NCIT_C187044 @default.
- Bb39f08cae445af10f54f4c71092fc00f annotatedTarget "The dihydrochloride salt form of NRC-2694, an orally bioavailable, small-molecule inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Upon oral administration, EGFR inhibitor NRC-2694 binds to and inhibits EGFR, which prevents EGFR-mediated signaling and leads to cell death in EGFR-expressing tumor cells. EGFR, a receptor tyrosine kinase mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization." @default.