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- Bb3b857607527f49e054be03990d76f73 NCIT_P378 "NCI" @default.
- Bb3b857607527f49e054be03990d76f73 type Axiom @default.
- Bb3b857607527f49e054be03990d76f73 annotatedProperty IAO_0000115 @default.
- Bb3b857607527f49e054be03990d76f73 annotatedSource NCIT_C1630 @default.
- Bb3b857607527f49e054be03990d76f73 annotatedTarget "A recombinant peptide, which is chemically identical or similar to the endogenous cytokine interleukin-14 (IL-14). The cytokine inhibits immunoglobulin secretion and selectively expands activated B-cell subpopulations. An IL-14 receptor is found on activated B-cells, but not in resting B-cells. This agent is unrelated to other cytokines but has homology with complement factor Bb. Autocrine or paracrine production of IL-14 may play a significant role in the rapid proliferation of aggressive non-Hodgkin lymphoma (NHL-B). Interrupting this pathway could be a useful goal of therapy for patients resistant to conventional chemotherapy." @default.