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- Bb44ca7a3e44d0cbd61f7543dc0268c78 NCIT_P378 "NCI" @default.
- Bb44ca7a3e44d0cbd61f7543dc0268c78 type Axiom @default.
- Bb44ca7a3e44d0cbd61f7543dc0268c78 annotatedProperty IAO_0000115 @default.
- Bb44ca7a3e44d0cbd61f7543dc0268c78 annotatedSource NCIT_C84836 @default.
- Bb44ca7a3e44d0cbd61f7543dc0268c78 annotatedTarget "An orally bioavailable, synthetic, second-generation small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor LAM-003A selectively binds to Hsp90, thereby inhibiting its chaperone function and promoting the degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; this agent may inhibit the growth and survival of a wide variety of cancer cell types. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stability, and degradation of many oncogenic signaling proteins." @default.