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- Bb4554446dd8fdbfa666f0a4d7f97cb4b NCIT_P378 "NCI" @default.
- Bb4554446dd8fdbfa666f0a4d7f97cb4b type Axiom @default.
- Bb4554446dd8fdbfa666f0a4d7f97cb4b annotatedProperty IAO_0000115 @default.
- Bb4554446dd8fdbfa666f0a4d7f97cb4b annotatedSource NCIT_C1319 @default.
- Bb4554446dd8fdbfa666f0a4d7f97cb4b annotatedTarget "The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression." @default.