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- Bb4756712ac75fc599f80e308e32c850a NCIT_P378 "NCI" @default.
- Bb4756712ac75fc599f80e308e32c850a type Axiom @default.
- Bb4756712ac75fc599f80e308e32c850a annotatedProperty IAO_0000115 @default.
- Bb4756712ac75fc599f80e308e32c850a annotatedSource NCIT_C52174 @default.
- Bb4756712ac75fc599f80e308e32c850a annotatedTarget "A cruciferous vegetable extract with potential chemopreventive activities. Broccoli sprout extract contains a high amount of sulforaphane, a naturally occurring isothiocyanate. Sulforaphane activates the transcription factor NF-E2-related factor 2 (Nrf2), a member of the basic leucine zipper family, which binds to and activates antioxidant-response elements (AREs). Subsequently, activated AREs mediate the transcription of antioxidant enzymes (particularly glutathione-S-transferase and quinone oxidoreductase), resulting in the detoxification of highly reactive carcinogens. AREs are cis-acting regulatory enhancer elements found in the 5' flanking region of many phase II detoxification enzymes." @default.