Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bb48f6ba15672dfc387bda5fd5e8fc86e> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bb48f6ba15672dfc387bda5fd5e8fc86e NCIT_P378 "NCI" @default.
- Bb48f6ba15672dfc387bda5fd5e8fc86e type Axiom @default.
- Bb48f6ba15672dfc387bda5fd5e8fc86e annotatedProperty IAO_0000115 @default.
- Bb48f6ba15672dfc387bda5fd5e8fc86e annotatedSource NCIT_C80325 @default.
- Bb48f6ba15672dfc387bda5fd5e8fc86e annotatedTarget "The trisodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix." @default.