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- Bb4b1e48bc4838860134089a1162ad40f NCIT_P378 "NCI" @default.
- Bb4b1e48bc4838860134089a1162ad40f type Axiom @default.
- Bb4b1e48bc4838860134089a1162ad40f annotatedProperty IAO_0000115 @default.
- Bb4b1e48bc4838860134089a1162ad40f annotatedSource NCIT_C121552 @default.
- Bb4b1e48bc4838860134089a1162ad40f annotatedTarget "Peripheral blood lymphocytes (PBLs) transduced with a gene encoding for a thyroglobulin (TG)-specific murine T-cell receptor (mTCR), with potential antineoplastic activity. PBLs are harvested from a thyroid cancer patient, and transfected with a retroviral vector that encodes the mTCR gene specific for the human TG antigen. The transduced PBLs are then expanded in culture. When reintroduced to the patient, these anti-TG mTCR-expressing PBLs target and bind to TG-overexpressing tumor cells, which results in both cytokine secretion and tumor cell lysis. TG is a thyroid-specific protein." @default.