Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bb4cb2cd68deb4347fd94eee38e2bb244> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bb4cb2cd68deb4347fd94eee38e2bb244 NCIT_P378 "NCI" @default.
- Bb4cb2cd68deb4347fd94eee38e2bb244 type Axiom @default.
- Bb4cb2cd68deb4347fd94eee38e2bb244 annotatedProperty IAO_0000115 @default.
- Bb4cb2cd68deb4347fd94eee38e2bb244 annotatedSource NCIT_C1796 @default.
- Bb4cb2cd68deb4347fd94eee38e2bb244 annotatedTarget "A synthetic hydroxamic acid derivative with antineoplastic activity. Vorinostat, a second generation polar-planar compound, binds to the catalytic domain of the histone deacetylases (HDACs). This allows the hydroxamic moiety to chelate zinc ion located in the catalytic pockets of HDAC, thereby inhibiting deacetylation and leading to an accumulation of both hyperacetylated histones and transcription factors. Hyperacetylation of histone proteins results in the upregulation of the cyclin-dependant kinase p21, followed by G1 arrest. Hyperacetylation of non-histone proteins such as tumor suppressor p53, alpha tubulin, and heat-shock protein 90 produces additional anti-proliferative effects. This agent also induces apoptosis and sensitizes tumor cells to cell death processes. Vorinostat crosses the blood-brain barrier." @default.