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- Bb52bfb2b298d6c85e9f0af2bc3ecdafe NCIT_P378 "NCI" @default.
- Bb52bfb2b298d6c85e9f0af2bc3ecdafe type Axiom @default.
- Bb52bfb2b298d6c85e9f0af2bc3ecdafe annotatedProperty IAO_0000115 @default.
- Bb52bfb2b298d6c85e9f0af2bc3ecdafe annotatedSource NCIT_C2130 @default.
- Bb52bfb2b298d6c85e9f0af2bc3ecdafe annotatedTarget "Any substance that inhibits glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme that catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine, the rate-limiting step in the biosynthesis of glutathione. Since glutathione is critical in protecting cells against oxidative stress, its depletion results in free radical-induced apoptosis." @default.