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- Bb54c12d61ca9ce35168c4a40938a4ba6 NCIT_P378 "NCI" @default.
- Bb54c12d61ca9ce35168c4a40938a4ba6 type Axiom @default.
- Bb54c12d61ca9ce35168c4a40938a4ba6 annotatedProperty IAO_0000115 @default.
- Bb54c12d61ca9ce35168c4a40938a4ba6 annotatedSource NCIT_C84866 @default.
- Bb54c12d61ca9ce35168c4a40938a4ba6 annotatedTarget "An orally bioavailable small-molecule androgen receptor modulator and CYP17 lyase inhibitor with potential antiandrogen activity. Galeterone exhibits three distinct mechanisms of action: 1) as an androgen receptor antagonist, 2) as a CYP17 lyase inhibitor and 3) by decreasing overall androgen receptor levels in prostate cancer tumors, all of which may result in a decrease in androgen-dependent growth signaling. Localized to the endoplasmic reticulum (ER), the cytochrome P450 enzyme CYP17 (P450C17 or CYP17A1) exhibits both 17alpha-hydroxylase and 17,20-lyase activities, and plays a key role in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens." @default.