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- Bb5af848dae4a645618ee7d5b70b6bcea NCIT_P378 "NCI" @default.
- Bb5af848dae4a645618ee7d5b70b6bcea type Axiom @default.
- Bb5af848dae4a645618ee7d5b70b6bcea annotatedProperty IAO_0000115 @default.
- Bb5af848dae4a645618ee7d5b70b6bcea annotatedSource NCIT_C90564 @default.
- Bb5af848dae4a645618ee7d5b70b6bcea annotatedTarget "An orally bioavailable inhibitor of the proto-oncogene c-Met (also known as hepatocyte growth factor receptor (HGFR)) with potential antineoplastic activity. Capmatinib selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing constitutively activated c-Met protein. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays key roles in tumor cell proliferation, survival, invasion, metastasis, and tumor angiogenesis." @default.