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- Bb6e439372deff44f2f5583fdb7f89837 NCIT_P378 "NCI" @default.
- Bb6e439372deff44f2f5583fdb7f89837 type Axiom @default.
- Bb6e439372deff44f2f5583fdb7f89837 annotatedProperty IAO_0000115 @default.
- Bb6e439372deff44f2f5583fdb7f89837 annotatedSource NCIT_C1806 @default.
- Bb6e439372deff44f2f5583fdb7f89837 annotatedTarget "A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. (NCI04)" @default.