Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bb6ff37e75c9b46d67a2441fd1700adb5> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bb6ff37e75c9b46d67a2441fd1700adb5 NCIT_P378 "NCI" @default.
- Bb6ff37e75c9b46d67a2441fd1700adb5 type Axiom @default.
- Bb6ff37e75c9b46d67a2441fd1700adb5 annotatedProperty IAO_0000115 @default.
- Bb6ff37e75c9b46d67a2441fd1700adb5 annotatedSource NCIT_C19064 @default.
- Bb6ff37e75c9b46d67a2441fd1700adb5 annotatedTarget "Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus self-peptides in a process called positive selection under the influence of epithelial cells in the thymic cortex. Positively-selected thymic T cell precursors (thymocytes) then progress through a process called negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction where self-reactive, and potentially autoimmunity-inducing, thymocytes are deleted. Thymocytes simultaneously progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor. They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells." @default.