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- Bb70869bebf2c15f9fc1db7b6e66ed1a0 NCIT_P378 "NCI" @default.
- Bb70869bebf2c15f9fc1db7b6e66ed1a0 type Axiom @default.
- Bb70869bebf2c15f9fc1db7b6e66ed1a0 annotatedProperty IAO_0000115 @default.
- Bb70869bebf2c15f9fc1db7b6e66ed1a0 annotatedSource NCIT_C192227 @default.
- Bb70869bebf2c15f9fc1db7b6e66ed1a0 annotatedTarget "An orally bioavailable, selective inhibitor of human fibroblast growth factor receptor 3 (FGFR3), with potential antineoplastic activity. Upon oral administration, FGFR3 inhibitor LOXO-435 specifically targets and binds to FGFR3, including FGFR3 gatekeeper resistance mutations. This blocks FGFR3-mediated signaling and leads to an inhibition of tumor cell proliferation in FGFR3-overexpressing cells. FGFR3, a receptor tyrosine kinase, is involved in angiogenesis and in the proliferation, differentiation, and survival of tumor cells. FGFR3 expression is associated with poor prognosis. It is overexpressed and/or mutated by certain tumor cell types." @default.