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- Bb7c57a6db26af89c2a7089d2443d4509 NCIT_P378 "NCI" @default.
- Bb7c57a6db26af89c2a7089d2443d4509 type Axiom @default.
- Bb7c57a6db26af89c2a7089d2443d4509 annotatedProperty IAO_0000115 @default.
- Bb7c57a6db26af89c2a7089d2443d4509 annotatedSource NCIT_C29061 @default.
- Bb7c57a6db26af89c2a7089d2443d4509 annotatedTarget "The propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production." @default.