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- Bb88913f5cd93bad71ddb462a851edd93 NCIT_P378 "NCI" @default.
- Bb88913f5cd93bad71ddb462a851edd93 type Axiom @default.
- Bb88913f5cd93bad71ddb462a851edd93 annotatedProperty IAO_0000115 @default.
- Bb88913f5cd93bad71ddb462a851edd93 annotatedSource NCIT_C189803 @default.
- Bb88913f5cd93bad71ddb462a851edd93 annotatedTarget "A bivalent booster vaccine consisting of elasomeran, a lipid nanoparticle (LNP) encapsulating a messenger RNA (mRNA) encoding the prefusion stabilized spike (S) protein of the SARS-CoV-2 Wuhan-Hu-1 strain (original), and imelasomeran, a LNP encapsulating mRNA encoding the prefusion stabilized S-protein of the SARS-CoV-2 Omicron variant B.1.1.529, with potential immunizing activity against SARS-CoV-2. Upon administration of elasomeran/imelasomeran, the LNP binds to the plasma membrane of cells and releases the mRNA into the cells. The mRNA is then translated by ribosomes to produce the SARS-CoV-2 S protein. This may activate both humoral and cellular immune responses which may result in protection against SARS-CoV-2 infection." @default.