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- Bb8bc20e3de947eec988060d1e00bfc0c NCIT_P378 "NCI" @default.
- Bb8bc20e3de947eec988060d1e00bfc0c type Axiom @default.
- Bb8bc20e3de947eec988060d1e00bfc0c annotatedProperty IAO_0000115 @default.
- Bb8bc20e3de947eec988060d1e00bfc0c annotatedSource NCIT_C189976 @default.
- Bb8bc20e3de947eec988060d1e00bfc0c annotatedTarget "A fixed two-agent injectable combination of the trihydrate form of meropenem, a broad-spectrum synthetic beta-lactam carbapenem antibiotic, and vaborbactam, a cyclic boronic acid beta-lactamase inhibitor, with antibacterial activity against susceptible bacteria. Upon administration of meropenem trihydrate/vaborbactam, meropenem binds to and inactivates penicillin-binding proteins (PBPs) on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linkage of peptidoglycan chains critical for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Vaborbactam binds to and inhibits beta-lactamase, thereby inhibiting the breakdown of meropenem, and increases the activity and therapeutic effect of meropenem." @default.