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- Bb9080a69d4337192dd0a97561bf2da53 NCIT_P378 "NCI" @default.
- Bb9080a69d4337192dd0a97561bf2da53 type Axiom @default.
- Bb9080a69d4337192dd0a97561bf2da53 annotatedProperty IAO_0000115 @default.
- Bb9080a69d4337192dd0a97561bf2da53 annotatedSource NCIT_C1094 @default.
- Bb9080a69d4337192dd0a97561bf2da53 annotatedTarget "A fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Administered parenterally as a phosphate salt, fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. (NCI04)" @default.