Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bb9764550152b9f5b3fd0b5e6d9aed6e9> ?p ?o ?g. }
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- Bb9764550152b9f5b3fd0b5e6d9aed6e9 NCIT_P378 "NCI" @default.
- Bb9764550152b9f5b3fd0b5e6d9aed6e9 type Axiom @default.
- Bb9764550152b9f5b3fd0b5e6d9aed6e9 annotatedProperty IAO_0000115 @default.
- Bb9764550152b9f5b3fd0b5e6d9aed6e9 annotatedSource NCIT_C104414 @default.
- Bb9764550152b9f5b3fd0b5e6d9aed6e9 annotatedTarget "A substance that inhibits protein geranylgeranyltransferase type 1 (GGTase-I), with potential antineoplastic activity. GGTase-I is involved in the posttranslational modification of a number of oncogenic GTPases, including K-Ras, N-Ras, RhoA, RhoC, Cdc42, RalA, RalB and Rac1. Inhibition of the prenylation of these oncogenic proteins inhibits both their oncogenic activity and membrane localization. This may result in cell cycle arrest and apoptosis. Protein geranylgeranylation, catayzed by GGTase-I, plays a critical role in malignant transformation and cancer cell proliferation, migration and invasion." @default.