Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bb9b2aad90b4726d73327c6d8e7c452e2> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bb9b2aad90b4726d73327c6d8e7c452e2 NCIT_P378 "NCI" @default.
- Bb9b2aad90b4726d73327c6d8e7c452e2 type Axiom @default.
- Bb9b2aad90b4726d73327c6d8e7c452e2 annotatedProperty IAO_0000115 @default.
- Bb9b2aad90b4726d73327c6d8e7c452e2 annotatedSource NCIT_C1258 @default.
- Bb9b2aad90b4726d73327c6d8e7c452e2 annotatedTarget "A synthetic dihydrotriazine derivative with antineoplastic properties. As an antifolate agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate reductase (DHFR), resulting in decreased tetrahydrofolate production and interference with thymidylate synthesis. Unlike MTX, this agent is not converted to polyglutamate forms. Triazinate also inhibits the transport of folates and may be selectively toxic to MTX-resistant tumor cells. (NCI04)" @default.