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- Bb9d3bbd2750a2c3fd1b8e39e77a89d54 NCIT_P378 "NCI" @default.
- Bb9d3bbd2750a2c3fd1b8e39e77a89d54 type Axiom @default.
- Bb9d3bbd2750a2c3fd1b8e39e77a89d54 annotatedProperty IAO_0000115 @default.
- Bb9d3bbd2750a2c3fd1b8e39e77a89d54 annotatedSource NCIT_C20669 @default.
- Bb9d3bbd2750a2c3fd1b8e39e77a89d54 annotatedTarget "Human TFIIIB Subunit Genes, BDP1, BRF1, and, BRF2, encode protein subunits of RNA Polymerase III Transcription Initiation Factor IIIB, required for RNA polymerase III transcription. Transcription begins with TFIIIC recognition of promoter A and B boxes and TFIIIA, TFIIIB, and RNA polymerase III binding. 90-kDa BRF1 contains a C-terminal HMG2-related region and an N-terminal TFII2B-related sequence. 50-kDa BRF2 has a zinc ribbon domain and a core domain, necessary for complex formation with DNA. Involved in nucleation of a polymerase III initiation complex, BRF2 does not directly bind DNA but interacts with TBP, which binds cooperatively to the promoter. TBP, an essential component of TFIIIB, binds the highly charged C-terminus of BRF1. Highly hydrophilic BDP1 contains a DNA-ligase A1 ATP-dependent binding site and several potential phosphorylation sites. (NCI)" @default.