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- Bba4776d55e7e990f1cb2b95652928d90 NCIT_P378 "NCI" @default.
- Bba4776d55e7e990f1cb2b95652928d90 type Axiom @default.
- Bba4776d55e7e990f1cb2b95652928d90 annotatedProperty IAO_0000115 @default.
- Bba4776d55e7e990f1cb2b95652928d90 annotatedSource NCIT_C338 @default.
- Bba4776d55e7e990f1cb2b95652928d90 annotatedTarget "An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)" @default.